diff --git a/docs/release-notes.md b/docs/release-notes.md
index 89883f87..4de0fa66 100644
--- a/docs/release-notes.md
+++ b/docs/release-notes.md
@@ -10,6 +10,8 @@
 ## Upcoming release
 * For players:
   * The SMAPI installer now also detects game folders listed in Steam's `.vdf` library data on Windows (thanks to pizzaoverhead!).
+  * SMAPI now prevents mods from enabling Harmony debug mode, which impacts performance and creates a file on your desktop.  
+    _You can allow debug mode by editing `smapi-internal/config.json` in your game folder._
   * Optimized performance and memory usage (thanks to atravita!).
   * Other internal optimizations.
   * Added more file extensions to ignore when searching for mod folders: `.7z`, `.tar`, `.tar.gz`, and `.xcf` (thanks to atravita!).
diff --git a/src/SMAPI/Framework/Models/SConfig.cs b/src/SMAPI/Framework/Models/SConfig.cs
index 9444c046..b3061fba 100644
--- a/src/SMAPI/Framework/Models/SConfig.cs
+++ b/src/SMAPI/Framework/Models/SConfig.cs
@@ -23,7 +23,8 @@ namespace StardewModdingAPI.Framework.Models
             [nameof(LogNetworkTraffic)] = false,
             [nameof(RewriteMods)] = true,
             [nameof(UseRawImageLoading)] = true,
-            [nameof(UseCaseInsensitivePaths)] = Constants.Platform is Platform.Android or Platform.Linux
+            [nameof(UseCaseInsensitivePaths)] = Constants.Platform is Platform.Android or Platform.Linux,
+            [nameof(SuppressHarmonyDebugMode)] = true
         };
 
         /// <summary>The default values for <see cref="SuppressUpdateChecks"/>, to log changes if different.</summary>
@@ -79,6 +80,9 @@ namespace StardewModdingAPI.Framework.Models
         /// <summary>The colors to use for text written to the SMAPI console.</summary>
         public ColorSchemeConfig ConsoleColors { get; set; }
 
+        /// <summary>Whether to prevent mods from enabling Harmony's debug mode, which impacts performance and creates a file on your desktop. Debug mode should never be enabled by a released mod.</summary>
+        public bool SuppressHarmonyDebugMode { get; set; }
+
         /// <summary>The mod IDs SMAPI should ignore when performing update checks or validating update keys.</summary>
         public HashSet<string> SuppressUpdateChecks { get; set; }
 
@@ -99,8 +103,9 @@ namespace StardewModdingAPI.Framework.Models
         /// <param name="useCaseInsensitivePaths">>Whether to make SMAPI file APIs case-insensitive, even on Linux.</param>
         /// <param name="logNetworkTraffic">Whether SMAPI should log network traffic.</param>
         /// <param name="consoleColors">The colors to use for text written to the SMAPI console.</param>
+        /// <param name="suppressHarmonyDebugMode">Whether to prevent mods from enabling Harmony's debug mode, which impacts performance and creates a file on your desktop. Debug mode should never be enabled by a released mod.</param>
         /// <param name="suppressUpdateChecks">The mod IDs SMAPI should ignore when performing update checks or validating update keys.</param>
-        public SConfig(bool developerMode, bool? checkForUpdates, bool? paranoidWarnings, bool? useBetaChannel, string gitHubProjectName, string webApiBaseUrl, string[]? verboseLogging, bool? rewriteMods, bool? useRawImageLoading, bool? useCaseInsensitivePaths, bool? logNetworkTraffic, ColorSchemeConfig consoleColors, string[]? suppressUpdateChecks)
+        public SConfig(bool developerMode, bool? checkForUpdates, bool? paranoidWarnings, bool? useBetaChannel, string gitHubProjectName, string webApiBaseUrl, string[]? verboseLogging, bool? rewriteMods, bool? useRawImageLoading, bool? useCaseInsensitivePaths, bool? logNetworkTraffic, ColorSchemeConfig consoleColors, bool? suppressHarmonyDebugMode, string[]? suppressUpdateChecks)
         {
             this.DeveloperMode = developerMode;
             this.CheckForUpdates = checkForUpdates ?? (bool)SConfig.DefaultValues[nameof(this.CheckForUpdates)];
@@ -114,6 +119,7 @@ namespace StardewModdingAPI.Framework.Models
             this.UseCaseInsensitivePaths = useCaseInsensitivePaths ?? (bool)SConfig.DefaultValues[nameof(this.UseCaseInsensitivePaths)];
             this.LogNetworkTraffic = logNetworkTraffic ?? (bool)SConfig.DefaultValues[nameof(this.LogNetworkTraffic)];
             this.ConsoleColors = consoleColors;
+            this.SuppressHarmonyDebugMode = suppressHarmonyDebugMode ?? (bool)SConfig.DefaultValues[nameof(this.SuppressHarmonyDebugMode)];
             this.SuppressUpdateChecks = new HashSet<string>(suppressUpdateChecks ?? Array.Empty<string>(), StringComparer.OrdinalIgnoreCase);
         }
 
diff --git a/src/SMAPI/Framework/SCore.cs b/src/SMAPI/Framework/SCore.cs
index 114c4bb3..3e6cd853 100644
--- a/src/SMAPI/Framework/SCore.cs
+++ b/src/SMAPI/Framework/SCore.cs
@@ -501,6 +501,15 @@ namespace StardewModdingAPI.Framework
                     return;
                 }
 
+                /*********
+                ** Prevent Harmony debug mode
+                *********/
+                if (HarmonyLib.Harmony.DEBUG && this.Settings.SuppressHarmonyDebugMode)
+                {
+                    HarmonyLib.Harmony.DEBUG = false;
+                    this.Monitor.LogOnce("A mod enabled Harmony debug mode, which impacts performance and creates a file on your desktop. SMAPI will try to keep it disabled. (You can allow debug mode by editing the smapi-internal/config.json file.)", LogLevel.Warn);
+                }
+
 #if SMAPI_DEPRECATED
                 /*********
                 ** Reload assets when interceptors are added/removed
diff --git a/src/SMAPI/SMAPI.config.json b/src/SMAPI/SMAPI.config.json
index 97e8e00c..2d4239ba 100644
--- a/src/SMAPI/SMAPI.config.json
+++ b/src/SMAPI/SMAPI.config.json
@@ -54,12 +54,6 @@ copy all the settings, or you may cause bugs due to overridden changes in future
      */
     "UseCaseInsensitivePaths": null,
 
-    /**
-     * Whether to use the experimental Pintail API proxying library, instead of the original
-     * proxying built into SMAPI itself.
-     */
-    "UsePintail": true,
-
     /**
      * Whether to use raw image data when possible, instead of initializing an XNA Texture2D
      * instance through the GPU.
@@ -138,6 +132,14 @@ copy all the settings, or you may cause bugs due to overridden changes in future
         }
     },
 
+    /**
+     * Whether to prevent mods from enabling Harmony's debug mode, which impacts performance and
+     * creates a file on your desktop. Debug mode should never be enabled by a released mod.
+     *
+     * If you actually need debug mode to test your own mod, set this to false.
+     */
+    "SuppressHarmonyDebugMode": true,
+
     /**
      * The mod IDs SMAPI should ignore when performing update checks or validating update keys.
      */